Indian Journal of Research in Homeopathy

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 9  |  Issue : 4  |  Page : 245--249

Effects of Zingiber officinale Aqueous Leaf Extract on Vincristine-Induced Kidney Damage in Adult Wistar Rats


Richard O Agbonluai Ehimigbai, Afokeoghene Eseoghene Akpobaro 
 Department of Anatomy, University of Benin, Benin City, Edo, Nigeria

Correspondence Address:
Dr. Richard O Agbonluai Ehimigbai
Department of Anatomy, University of Benin, Benin City, Edo
Nigeria

Background: Vincristine, although used as a chemotherapy drug, has been reported to induce nephrotoxicity, while Zingiber officinale, a medicinal plant, possesses antioxidant, antiapoptotic, and antitumorigenic properties. Aim and Objectives: In this study, we examined the effects of Z. officinale against vincristine-induced kidney damage by analyzing renal function, enzymatic antioxidants, and renal tissue. Materials and Methods: Thirty adult Wistar rats, weighing between 140 g and 185 g, were assigned into six groups of five animals each. Groups A, B, C, D, E, and F received 1 ml of distilled water, 200 mg/kg of Z. officinale aqueous extract, 1000 mg/kg of Z. officinale aqueous extract, 50 μg/kg of vincristine only, 200 mg/kg of Z. officinale aqueous extract and 50 μg/kg of vincristine, and 1000 mg/kg of Z. officinale aqueous extract and 50 μg/kg of vincristine, respectively. Administration of vincristine was by a 10-day intraperitoneal injection, while that of Z. officinale was by gavage, for a period of 28 days. Food and water were provided across all groups, ad libitum. Results: Vincristine significantly (P < 0.05) increased the levels of creatinine, urea, chloride, and malondialdehyde while having a reducing effect on the levels of superoxide dismutase and catalase. The histology revealed that vincristine caused a distortion of the renal architecture. Conclusion: The administration of Z. officinale mitigated the aforementioned debilitating effects of vincristine.


How to cite this article:
Ehimigbai RO, Akpobaro AE. Effects of Zingiber officinale Aqueous Leaf Extract on Vincristine-Induced Kidney Damage in Adult Wistar Rats.Niger J Exp Clin Biosci 2021;9:245-249


How to cite this URL:
Ehimigbai RO, Akpobaro AE. Effects of Zingiber officinale Aqueous Leaf Extract on Vincristine-Induced Kidney Damage in Adult Wistar Rats. Niger J Exp Clin Biosci [serial online] 2021 [cited 2022 Jul 7 ];9:245-249
Available from: https://www.njecbonline.org/article.asp?issn=2348-053X;year=2021;volume=9;issue=4;spage=245;epage=249;aulast=Ehimigbai;type=0