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ORIGINAL ARTICLE
Year : 2022  |  Volume : 10  |  Issue : 2  |  Page : 60-64

Evaluation of the glycemic and lipidemic effect of Murraya koenigii (L.) spreng ethanolic leaf extract in alloxan-induced diabetic rats


1 Department of Physiology, College of Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State; Department of Physiology, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria
2 Department of Physiology, College of Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State, Nigeria
3 Department of Physiology, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria
4 Department of Physiology, College of Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State, Calabar, Nigeria

Correspondence Address:
Mr. Azubuike Raphael Nwaji
Department of Physiology, College of Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njecp.njecp_9_22

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Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia and often accompanied by lipid abnormalities. The ongoing search for natural antidiabetic remedies is concentrated on plants used as such in ethnomedicine. Murraya koenigii is also known as curry leaf plant, belonging to the family Rutaceae. Few studies have shown the activity of M. koenigii in management of diabetes mellitus and lipidemic effect. Aim: This study evaluated the effect of M. koenigii leaf extract on glucose tolerance and lipid profile in alloxan-induced diabetic male rats. Materials and Methods: Twenty male Wistar rats were used for the study. The animals were randomly selected into four groups (1, 2, 3, and 4) of five rats each. Group 1 served as normal control, Group 2 as diabetic control, while Groups 3 and 4 were diabetic and orally treated with 200 and 400 mg/kg body weight of M. koenigii extract, respectively. After 14 days of administration, oral glucose tolerance test was performed on overnight fasted rats. Thereafter, the animals were anesthetized and blood samples obtained were used for biochemical assay. Results: There was no significant differences (P < 0.05) in the glucose tolerance between the normal control and the M. koenigii (200 and 400 mg/kg)-treated groups. However, a significant increase (P < 0.05) between the diabetic control group and the normal control was noted at 30, 60, and 120 min following glucose load. Furthermore, there was no significant changes (P < 0.05) in the lipid parameters between the normal control and the treated groups of the alloxan-induced hyperglycemic rats. Conclusion: The results of this study suggest that ethanolic extract of M. koenigii administered for a 2-week period had no effect on the glucose tolerance and lipid profile of the alloxan-induced hyperglycemic rats.


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