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Year : 2022  |  Volume : 10  |  Issue : 2  |  Page : 47-52

Cystatin-c, beta-2-microglobulin, and other determinants of renal function in preeclampsia

Department of Chemical Pathology, University of Benin, Benin City, Edo State, Nigeria

Correspondence Address:
Dr. Ejuoghanran Oriseseyigbemi Onovughakpo-Sakpa
Department of Chemical Pathology, University of Benin, Benin City, Edo State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njecp.njecp_5_22

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Context: Preeclampsia is a serious complication of pregnancy which is avoidable with timely and effective care. Aim: The aim of this study was to monitor the renal status using biochemical indices such as serum cystatin-c, beta-2-microglobulin (B2MG), and other renal function. Setting and Design: This was a cross-sectional descriptive study. Subjects and Methods: One hundred and sixty respondents (124 preeclamptics [PE] and 36 normotensive pregnant women [NPW]) participated in this study. Fresh mid-stream urine and venous blood samples were collected for the estimation of urine albumin and creatinine, plasma creatinine and urea, serum cystatin-c, and B2MG. Statistical Analysis Used: The Statistical Package for the Social Sciences version 16 with the level of significance set at P < 0.05 was used for statistical analysis. Results: Amongst the PE, 39 (31.5%) were mild cases while 85 (68.5%) were severe. Serum cystatin-c, B2MG, plasma creatinine and urine albumin-creatinine ratio (ACR) were higher in the PE than in the NPW while plasma urea was significantly (P < 0.05) higher in NPW than in PE. Cystatin-c was significantly (P < 0.05) higher in PE than in NPW in the 3rd trimester while B2MG was significantly (P < 0.05) higher in PE than in NPW in the 2nd and 3rd trimesters. Urine ACR and serum B2MG were significantly (P < 0.05) higher in severe than in mild PE. There was a significant (P < 0.05) positive correlation between serum cystatin-c and urine ACR and between B2MG and plasma creatinine. Serum cystatin-c was increased throughout the period of gestation with higher values in the 3rd trimester while serum B2MG was higher in the 2nd trimester. Conclusion: In comparison to other biological indices of renal function, serum B2MG and serum cystatin-c could be more useful in the early detection and severity of preeclampsia.

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