| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 10
| Issue : 1 | Page : 9-14 |
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Quercetin improves mood-related behaviors in mice subjected to paradoxical sleeplessness
Anthony Taghogho Eduviere, Lily Oghenevovwero Otomewo, Onyekachukwu Glory Anyanwu, Favour Oghenekome Igari, Oghenefejiro Juliana Okorigba
Department of Pharmacology, Delta State University, Abraka, Nigeria
Correspondence Address:
Ms. Lily Oghenevovwero Otomewo
Delta State University, Abraka
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/njecp.njecp_41_21
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Context: Food supplements are a widely consumed class of pharmaceuticals. Quercetin (QCT) is a bioflavonoid with reported benefits in various disease conditions. Aims: The present study sought to evaluate the potential protective role of QCT against anxiety-like and antisocial behavior in mice exposed to persistent wakefulness. Settings and Design: The sleep deprivation protocol used in this research was the multiple platforms over the water model. Subjects and Methods: Thirty male albino mice were randomly divided into five groups, each consisting of six mice: Group 1 was considered the naive group; Group 2 was considered the model control. Groups 3 and 4 received QCT (25 and 50 mg/kg; p. o.) and Group 5 received astaxanthin (50 mg/kg; p. o.) in addition to being sleep-deprived respectively. The mice in groups 2–5 received their respective treatment for 7 days but were subjected to a 72 h sleep deprivation from day 4. On day 8, behavioral activities were monitored, and then, animals were sacrificed 1 h after the drug administration. Brain samples were subsequently collected for the biochemical and histopathological analysis. Statistical Analysis Used: One-way analysis of variance. Results: The results indicate that persistent wakefulness-induced anxiety such as symptoms and depression-like behavior in mice. In addition, oxidative stress was significant in sleep-deprived group with an enhancement in activity of prooxidants. However, upon pre-treatment with QCT, such behaviors and suppression of antioxidant molecules were reversed. Conclusions: In conclusion, the present finding showed that QCT could attenuate the impairment of antioxidant enzymes, reduce anxiety, and depression-like behaviors caused by sleep deprivation in mice.
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