Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 10  |  Issue : 1  |  Page : 29-33

Association between thyroid hormones and renal function in patients with chronic kidney disease: A hospital-based cross-sectional study among Nigerians


1 Department of Medical Laboratory Science, Babcock University, IlishanRemo, Ogun-state, Nigeria
2 Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo-state, Nigeria
3 Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo-state, Nigeria

Correspondence Address:
Dr. Ayodeji Folorunsho Ajayi
Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo-state
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njecp.njecp_2_22

Rights and Permissions

Background: A seemingly exciting link has been reported to exist between thyroid state and renal function, thus establishing a thyroid–renal axis. However, findings from studies aimed at evaluating this axis have not been consistent. Therefore, we hypothesized that estimated glomerular filtration rate (eGFR), a surrogate of incident chronic kidney disease (CKD), could be independently predicted by thyroid-stimulating hormone (TSH), free thyroxin (fT4), and free triiodothyronine (fT3). Materials and Methods: We compared the serum concentrations of TSH, fT4, and fT3 in patients with CKD after classifying them into stage III, stage IV, or end-stage renal disease based on the National Kidney Foundation Classification Criteria. Results: Our results showed that the concentrations of TSH, fT4, and fT3 were comparable across the different stages of CKD. Findings from the study also indicated that thyroid hormones were not associated with CKD, nor were they predictors of CKD development. Conclusion: The present study demonstrates that TSH, fT4, and fT3 are not effective risk factors that are independently associated with declined eGFR in patients with CKD. Our findings also revealed that these hormones are not useful tools in the early detection of CKD.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed294    
    Printed8    
    Emailed0    
    PDF Downloaded38    
    Comments [Add]    

Recommend this journal