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ORIGINAL ARTICLE
Year : 2022  |  Volume : 10  |  Issue : 1  |  Page : 24-28

Ameliorative activities and safety of Moringa Oleifera oil and Nigella Sativa oil on diet-induced hyperlipidemic male wistar rats


1 Department of Biochemistry, University of Benin, Benin City, Nigeria
2 Department of Medical Biochemistry, College of Medicine, Kaduna State University, Kaduna State, Nigeria
3 Department of Physiology, College of Medicine, Kaduna State University, Kaduna State, Nigeria
4 Department of Medical Biochemistry, Delta State University, Abraka, Nigeria
5 Department of Biological Sciences (Biochemistry Unit), Al-Hikmah University, Kwara State, Ilorin, Nigeria

Correspondence Address:
Dr. Oghenetega ThankGod Oweh
Department of Medical Biochemistry, College of Medicine, Kaduna State University KASU
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njecp.njecp_1_22

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Background: Numerous medicinal plants have been explored as therapy for hyperlipidemia which could be induced by a high-fat diet (HFD). Aims and Objectives: The ameliorative effects of Moringa oleifera oil and Nigella sativa oil and their safety on diet-induced hyperlipidemic Wistar rats were examined. Materials and Methods: Thirty Wistar rats were distributed into six groups of five each. Group 1 was the control group while the other groups were fed with HFD. Groups 3–6 were treated using 1 ml/kg BW of M. oleifera oil, 0.5 ml/kg BW M. oleifera oil, 1 ml/kg BW N. sativa oil, and 0.5 ml/kg BW N. sativa oil, respectively, for 10 days. The plasma total and tissue cholesterol, triglyceride, and high-density lipoprotein (HDL)-cholesterol concentrations as well as alkaline phosphatase (ALP), alanine aminotransferases (ALT), and aspartate aminotransferase (AST) activities were analyzed. Results: M. oleifera oil and N. sativa oil (1 ml/kg BW and 0.5 ml/kg BW) showed significant reduction at (P < 0.05) in total plasma cholesterol and lipid levels compared to the control group but had no significant effects on the activities of AST, ALT, and ALP. Conclusion: The study proved that M. oleifera and N. sativa oil ameliorate diet-induced hyperlipidemia in Wistar rats by reducing plasma cholesterol, triglyceride, and increasing HDL levels and show no adverse effects on the activities of the liver enzymes.


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