Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 10  |  Issue : 1  |  Page : 1-8

Glial fibrillary acid protein expression and behavioral changes in hippocampus following prenatal co-administration of ethyl acetate leaf fraction of Tamarindus Indica and aluminum chloride in wistar rats


1 Department of Human Anatomy, Faculty of Biomedical Sciences, Kampala International University, Kampala; Department of Human Anatomy, College of Medicine and Health Science, Ahmadu Bello University, Zaria, Nigeria
2 Department of Human Anatomy, College of Medicine and Health Science, Ahmadu Bello University, Zaria, Nigeria
3 Department of Human Anatomy, Federal University Dutse, Jigawa, Nigeria

Correspondence Address:
Dr. Ibe Michael Usman
Department of Human Anatomy, Faculty of Biomedical Sciences, Kampala International University, Kampala
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njecp.njecp_34_21

Rights and Permissions

Background: The endowment of various plant parts with important phytochemicals needed in the management of human health breeds lots of hope. The present study investigated glial fibrillary acid protein (GFAP) expression and hippocampal behavioral changes following prenatal co-administration of ethyl acetate leaf fraction of Tamarindus indica (EATI) and aluminum chloride (AlCl3) in male Wistar rat pups. Methodology: Twenty pregnant Wistar rats were divided into five groups (n = 4). Group 1 received distilled water, while the treatment Groups 2 to5 received 200 mg/kg of AlCl3, followed by 400 and 800 mg/kg EATI in Groups 3 and 4, respectively, and 300 mg/kg Vitamin E in Group 5. All administrations lasted for 14 days from prenatal day 7 till parturition. The male pups (n = 6) were curled for Morris water maze (MWM) from postnatal day (PoND) 16–20, then sacrificed humanely on PoND 21. The brain tissues were harvested for oxidative stress studies (OSS) and the demonstration of GFAP antibody. Result: The result of the MWM showed significantly high mean latency to locate the platform in Groups 2 and 5 when compared to the control group (P < 0.05). The OSS revealed significantly higher superoxide dismutase concentration in Groups 4 and 5 compared to that observed in Group 2. The GFAP studies revealed significantly higher immunoreactivity scores in Group 2 when compared to every other group (P < 0.05) in the CA1 hippocampal region. Conclusion: EATI was associated with some protective potential during prenatal aluminum chloride exposure in Wistar rats.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed651    
    Printed10    
    Emailed0    
    PDF Downloaded69    
    Comments [Add]    

Recommend this journal