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Year : 2016  |  Volume : 4  |  Issue : 2  |  Page : 35-41

Effects of adenosine and caffeine on blood glucose levels in rats

1 Department of Physiology, School of Medicine and Pharmacy, University of Rwanda College of Medicine and Health Sciences, Huye, Republic of Rwanda, East Africa
2 Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Kwara
3 Department of Physiology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria
4 Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria

Correspondence Address:
Dr. Abdullateef Isiaka Alagbonsi
Department of Physiology, School of Medicine and Pharmacy, University of Rwanda College of Medicine and Health Sciences, Huye, Republic of Rwanda
East Africa
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njecp.njecp_2_16

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Background: Reports from previous studies on the effects of adenosine and caffeine on blood glucose are controversial and inconclusive. The present study sought to investigate the effect of acute adenosine infusion and caffeine injection on blood glucose level in rats. Materials and Methods: Thirty-four male albino rats (300–400 g) were randomly divided in a blinded-fashion into six groups, namely, Group I (n = 6) received normal saline (0.1–0.2 ml), Group II (n = 6) received adenosine (347.8 μg/kg/min), Group III (n = 5) received caffeine (6 mg/kg), followed by adenosine (347.8 μg/kg/min), Group IV (n = 5) were diabetic rats that received adenosine (347.8 μg/kg/min), Group V (n = 6) received caffeine (6 mg/kg), and Group VI (n = 6) received nifedipine (300μg/kg), followed by caffeine (6 mg/kg). Administrations were done through the femoral vein, while blood samples were taken from the carotid artery for glucose measurement. Results: Adenosine caused a reduction in blood glucose level in normal and diabetic rats, though the reduction was more noticeable in diabetic rats. Pretreatment of rats with caffeine completely abolished the adenosine-induced reduction in blood glucose and produced an exaggerated increase in blood glucose comparable to the level seen in rats that received caffeine alone. Pretreatment of rats with nifedipine reduced the caffeine-induced hyperglycemia by two-third. Conclusion: This study suggests that adenosine receptors could be of therapeutic target in the treatment of Type 1 diabetes due to its blood glucose-lowering potential in both diabetic and normal rats. It also suggests that intracellular calcium mobilization is more implicated in caffeine-induced hyperglycemia than adenosine receptor antagonism, even though other unidentified mechanism(s) remain to be explored.

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