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Subacute effect of Vernonia amygdalina methanolic crude leaf extract on the hematological profile in albino Wistar rats
Thomas Nubila1, Nkoyo Imelda Nubila2, Ayodele Ukaejiofo3, Elvis Neba Shu2, Chukwubuzor U Okwuosa4, Chioli Pascal Chijioke2, Princess Orji1
1 Department of Medical Laboratory Sciences, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria
2 Department of Pharmacology, and Therapeutics, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria
3 Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Enugu State, Nigeria
4 Department of Histopathology, University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Enugu State, Nigeria
Correspondence Address:
Thomas Nubila
Department of Medical Laboratory Sciences, University of Nigeria, Enugu Campus, Enugu State
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2348-0149.123963
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Background: Vernonia amygdalina is among one of the most used medicinal plants with a higher safety and efficacy in managing a wide array of medical ailments. The objective of this study is to evaluate the subacute effects of the methanolic crude leaf extract of Vernonia amygdalina on the hematological profile in Albino Wistar rats. Materials and Methods: Thirty Albino rats were used for the study. They were equally grouped into five groups: A (control), B, C, D, and E groups. The test (B, C, D, and E) groups were gavaged with doses (10, 15, 25, and 40 mg/kg body weight, respectively) of Vernonia amygdalina leaf methanolic extract once daily, for nine days. Two milliliters of blood was collected from two animals each from each group on days three, six, and nine, for the determination of the hematological profile using a hematology analyzer. Results: Mean cell hemoglobin mean value showed a statistically significant increase (P < 0.05) in group C (15 mg/kg body weight). Similarly, a statistically significant increase (P < 0.01) was recorded in group E (40 mg/kg body weight) on day three, when compared with the control group A (untreated). However, only the mean value of the platelet count revealed a statistically significant decrease (P < 0.05) in group D (25 mg/kg body weight) on day six, when compared with the control. Conclusion: The subacute administration of Vernonia amygdalina methanolic crude leaf extract does not possess hematopoietic activities. |
