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Year : 2013  |  Volume : 1  |  Issue : 1  |  Page : 18-22

Increased bile flow rate and altered composition of bile induced by ethanolic leaf extract of Azadirachta indica (neem) in rats

1 Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria
2 Department of Biochemistry, College of Medical Sciences, University of Calabar, Calabar, Nigeria

Correspondence Address:
Ofem E Ofem
Department of Physiology, College of Medical Sciences, University of Calabar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2348-0149.123958

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Background: Azadirachta indica (neem) is an ever green tropical plant with ethno-medicinal uses; it is a very potent anti-malaria plant. There is a paucity of the scientific literature on the impact of A. indica on the biliary flow rate and bile composition, considering that alterations in bile composition may lead to gall stone. Aim: This study therefore sought to elucidate the impact of A. indica leaves extract on biliary flow rate and bile composition in rats. Materials And Methods: Eighteen (18) albino Wistar rats were randomly assigned into three groups of six rats each and fed on normal rat chow and/or 150 mg/kg, 300 mg/kg body weight of A. indica extract for 21 days. Results: The rate of bile secretion is in the control, low dose (LD) and high dose (HD) A. indica extract treated rats was 3.0 ± 0.02 ml/h, 5.60 ± 0.46 ml/h and 5.38 ± 0.32 ml/h respectively, showing a significant (P < 0.001) increase in LD and HD compared with control. Na + concentration increased significantly (P < 0.05) in the HD extract recipients compared with control. LDs of the extract increased K + significantly (P < 0.001) compared with control and HD. HDs of the extract increased Cl− concentration significantly (P < 0.05) compared with LD. HCO3 did not alter significantly among these groups. LDs of the extract significantly (P < 0.01) increased total cholesterol, total and unconjugated bilirubin concentrations, HDs reduced it. Conclusion: Hence, A. indica leaves extract increases bile flow rate, LDs of the extract increases cholesterol and bilirubin saturations while HDs reduces it.

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