Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 1  |  Issue : 1  |  Page : 14-17

Evaluation of memory status following administration of depo-provera in female wistar rats


1 Physiology Department, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
2 University of Nigeria, Enugu Campus, Enugu State, Nigeria

Correspondence Address:
Okojie Akhabue Kenneth
Physiology Department, University of Nigeria, Enugu Campus, Enugu State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2348-0149.123957

Rights and Permissions

Background: Medroxyprogesterone acetate (MPA) is the most commonly used progestin component of hormone therapy (HT). In vitro, MPA negatively impacts markers of neuronal health and exacerbates experimentally induced neurotoxicity. There is in vitro evidence that these factors are driven by GABAergic and neurotrophic systems. Whether these effects translate to a negative impact on brain function has not been tested in vivo, clinically or preclinically. Aim: The goal of the present study was to determine whether MPA exerts detrimental effects on cognitive function in actively reproducing rats using Y-maze apparatus. Materials and Methods: Twenty-four female rats were randomly selected into three groups. Control group, Low dose (100 mg/1 ml MPA) group, and High dose (200 mg/1 ml MPA) group, respectively. Dose was delivered by intramuscular injection for the period of 3 weeks. Result: Intramuscular administration of MPA resulted in a dose-dependent decrease in memory and locomotion activities of the female wistar rats (P < 0.05). Discussion: These findings suggest that MPA, the most commonly used progestin in HT, is detrimental to learning and two types of memory, and possibly modulates the GABAergic system in cognitive brain regions, in actively reproducing rats. These findings, combined with in vitro evidence that MPA is detrimental to neuronal health, indicates that MPA has negative effects for brain health and function. Conclusion: Therefore, MPA despite being effective in modulating hormonal interaction to prevent conception in actively reproducing females, learning and memory depression could be one of its adverse effects.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4072    
    Printed182    
    Emailed0    
    PDF Downloaded259    
    Comments [Add]    
    Cited by others 2    

Recommend this journal