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Effects of methanolic seed extract of Telfairia occidentalis on blood coagulation in Albino rats
Nubila Thomas1, Ukaejiofo Okem Ernest1, Nubila Imelda Nkoyo2, Shu Neba Elvis2, Okwuosa U Chukwubuzor3, Ukaejiofo C Ayodele4, Iyare E Eghosa5, Ogbuta Osule Ifeyinwa1
1 Department of Medical Laboratory Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria
2 Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria
3 Department of Oral and Maxillofacial Pathology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Enugu State, Nigeria, Nigeria
4 Department of Medical Rehabilitation, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria
5 Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria
Correspondence Address:
Nubila Thomas
Department of Medical Laboratory Sciences, Faculty of Health Sciences And Technology, University of Nigeria, Enugu Campus, Unec
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2348-0149.123943
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Background: Medicinal plants have played a key role in the world healthcare with about 80% of Africans depending on phytomedicine, which has shown a wide range of uses in the treatment of diseases especially priority diseases of Africa. The objective of this study was to investigate the sub-acute effects of methanolic seed extracts Telfairia Occidentalis on prothrombin time (PT), activated partial thromboplastin time (APTT), and platelet values in Albino Wistar rats. Materials and Methods: Thirty rats were equally divided into groups A (control), B, C, D, and E (test). Groups B, C, D, and E were gavaged with 20, 40, 80 and 160 mg/kg body weight, respectively, of the extract for 9 days. Four milliliters of venous blood was collected from each animal and 2 ml delivered into 0.25 ml tri-sodium citrate and K 3 ethylene diamine tetra acetic acid (EDTA) anticoagulant bottles for the determination of PT, APTT, and platelet values, respectively. Results: APTT showed a statistically significant increase in groups D (P < 0.01) and E (P < 0.05) when compared with the control on Day 3. Platelet value demonstrated a time-dependent statistically significant decrease (P < 0.05). Conclusion: In conclusion. T. occidentalis demonstrated sub-acute inhibitory effects on coagulation. |
